Interpreting meta-regression: application to recent controversies in antidepressants’ efficacy
نویسندگان
چکیده
منابع مشابه
Efficacy of antidepressants in juvenile depression: meta-analysis.
BACKGROUND The safety of antidepressants in children and adolescents is being questioned and the efficacy of these drugs in juvenile depression remains uncertain. AIMS To assess antidepressant efficacy in juvenile depression. METHOD Systematic review and meta-analysis of randomised controlled trials (RCTs) comparing responses to antidepressants, overall and by type, v. placebo in young peop...
متن کاملEfficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.
OBJECTIVE Late-life depression is an important public health issue, given the growing proportion of the elderly relative to the general population in the developed world. The purpose of this study was to examine the efficacy of antidepressants for the treatment of major depressive disorder (MDD) in elderly patients. DATA SOURCES PubMed/MEDLINE was searched for randomized, double-blind, placeb...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملMeta-analysis of Selective Serotonin Reuptake Inhibitors (SSRIs) Compared to Tricyclic Antidepressants (TCAs) in the Efficacy and Safety of Anti-depression Therapy in Parkinson᾽s Disease(PD) Patients
This meta-analysis aims to assess the efficacy and safety of SSRIs and TCAs in treatment of PD. A computer-base search was conducted of Pubmed, MEDLINE, EMBASE, Cochrane Controlled Trails Register (CCTR) up to December 2011. The random controlled clinic trials about SSRIs and TCAs in PD treatment were collected. Statistical analysis was completed using Review Manager, version 5.0. Five clinic c...
متن کاملInterpreting Complex Regression Models
Interpretation of a machine learning induced models is critical for feature engineering, debugging, and, arguably, compliance. Yet, best of breed machine learning models tend to be very complex. This paper presents a method for model interpretation which has the main benefit that the simple interpretations it provides are always grounded in actual sets of learning examples. The method is valida...
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ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2013
ISSN: 0277-6715
DOI: 10.1002/sim.5766